AG Scientific/Zotaromus/Z-2597/1 mg
商品编号：
Z-2597-1mg
品牌：
agscientific
市场价：
¥2198.20
美元价：
1648.65
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Zotarolimusisasemi-syntheticmacrocycliclactonepreparedfromrapamycinbypreparationofthe42-triflateester,followedbydisplacementwithtetrazoleandpurificationofthetwoisomericproducts.Thisstructuralchangeaffordsalessbioavailableproduct,apreferredprofileforsomeapplications.Likealltacrolimusanalogues,zotarolimusbindstoareceptorprotein(FKBP12).ThecomplexthenbindstomTORpreventingitfrominteractingwithtargetproteins.Zotarolimusisextensivelycitedintheliteraturewithover200citations.
AdditionalInformation
| Product# | Z-2597 |
|---|---|
| CAS# | 221877-54-9 |
| ChemicalName | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-DIHYDROXY-19,30-DIMETHOXY-12-((2R)-1-[(1S,3R,4S)-3-METHOXY-4-(1H-TETRAZOL-1-YL)CYCLOHEXYL]-2-PROPANYL)-15,17,21,23,29,35-HEXAMETHYL-11,36-DIOXA-4-AZATRICYCLO[30.3.1.04,9]HEXATRIACONTA-16,24 |
| Formula | C52H79N5O12 |
| MW | 966.2 |
| Appearance | Whitesolid |
| Purity | >95%byHPLC |
| MeltingPoint | 100-105°C |
| BoilingPoint | 1016.2±75.0°Cat760mmHg |
| StorageTemp | 4°C |
| TherapeuticArea | VascularDisorders |
| Use | Zotarolimusisusefulinthetreatmentofrestenosis |
| InChI | InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1 |
|---|---|
| SMILES | C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@@H]([C@@H](C4)OC)n5cnnn5)C)/C)O)OC)C)C)/C)OC |
