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AG Scientific/PRT4165, E3 ubiquitin ligase inhibitor/P-3327/50 mg
AG Scientific/PRT4165, E3 ubiquitin ligase inhibitor/P-3327/50 mg
商品编号：
P-3327-50mg
品牌：
agscientific
市场价：
¥5200.00
美元价：
3120.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α. PRT-4165 inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.
Additional Information
| Product # | P-3327 |
|---|---|
| CAS # | 31083-55-3 |
| Chemical Name | 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione |
| Formula | C15H9NO2 |
| MW | 235.24 |
| Appearance | Yellow solid |
| Purity | 98% by TLC NMR (Conforms) |
| Solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml with warming). |
| Storage Temp | RT (des.) |
Additional Information
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
