AG Scientific/Siomycin A/S-2771/2.5 mg
商品编号：
S-2771-2.5mg
品牌：
agscientific
市场价：
¥23782.00
美元价：
14269.20
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
*Please inquire the availability for this product. Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Siomycin is a potent inhibitor of the oncogenic transcription factor, FoxM1. The reduced transcription activity is reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes, Cdc25B, survivin and CENPB. In vitro, siomycin inhibits FoxM1-induced cell growth on soft agar and selectively kills transformed but not normal cells.
Additional Information
| Synonyms | Mutabilycin, Sporangiomycin, 6741-21, Mutabillicin |
|---|---|
| Product # | S-2771 |
| CAS # | 12656-09-6 |
| Formula | C71H81N19O18S5 |
| MW | 1648.9 |
| Appearance | White solid |
| Purity | >95% by HPLC |
| Solubility | DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water |
| Storage Temp | -20°C |
| Therapeutic Area | Infectious Diseases |
| Use | Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity |
Additional Information
| MDL Number | MFCD01750111 |
|---|---|
| InChI | InChI=1S/C71H81N19O18S5/c1-14-37-64-83-44(22-109-64)61(103)89-52(70(13,107)34(12)93)67-85-43(23-112-67)59(101)88-48-33(11)108-68(106)40-19-36(31(9)91)35-15-16-38(50(94)49(35)79-40)78-46(25(2)3)62(104)77-29(7)56(98)74-27(5)55(97)75-30(8)57(99)90-71(69-86-45(24-113-69)60(102)87-47(32(10)92)63(105)81-37)18-17-39(80-51(71)41-20-111-66(48)82-41)65-84-42(21-110-65)58(100)76-28(6)54(96)73-26(4)53(72)95/h14-16,19-21,23-25,30-34,38,44,46-48,50-52,78,91-94,107H,4-7,17-18,22H2,1-3,8-13H3,(H2,72,95)(H,73,96)(H,74,98)(H,75,97)(H,76,100)(H,77,104)(H,81,105)(H,87,102)(H,88,101)(H,89,103)(H,90,99)/b37-14-/t30-,31-,32+,33+,34+,38+,44+,46-,47-,48-,50-,51+,52+,70+,71+/m0/s1 |
| SMILES | C/C=C1/C2=N[C@H](CS2)C(=O)N[C@H](c3nc(cs3)C(=O)N[C@@H]4c5nc(cs5)[C@@H]6[C@](CCC(=N6)c7nc(cs7)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)(c8nc(cs8)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)[C@@H](NC(=O)C(=C)NC(=O)C(=C)NC(=O)[C@@H](N[C@@H]9C=Cc1c(cc(nc1[C@H]9O)C(=O)O[C@@H]4C)[C@H](C)O)C(C)C)C)[C@@](C)([C@@H](C)O)O |
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
