AG Scientific/Panobinostat/P-2380/25 mg
商品编号：
P-2380-25mg
品牌：
agscientific
市场价：
¥21235.00
美元价：
12741.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Panobinostat(LBH589)isahighlypotentinhibitorofbothhistonedeacetylase1(HDAC1)activityandtumourcellproliferationinvitro.TheICvaluesofHDACisozymesHDAC1-IPAc-H4,HDAC8,MALunselective,B61HDAC1andB12HDAC6are0.230.06,28329,754,475and8912nM,respectively.AndtoA2780proliferation,ICvalueis4.61.8nM.
AdditionalInformation
| Synonyms | LBH589,LBN-589,NVP-LBH590 |
|---|---|
| Product# | P-2380 |
| CAS# | 404950-80-7 |
| ChemicalName | (E)-N-HYDROXY-3-[4-[[2-(2-METHYL-1H-INDOL-3-YL)ETHYLAMINO]METHYL]PHENYL]PROP-2-ENAMIDE |
| Formula | C21H23N3O2 |
| MW | 349.43 |
| Appearance | CrystallineSolid |
| Purity | 99%byHPLC |
| Solubility | DMSO |
| MeltingPoint | 115°C |
| StorageTemp | -20°C |
| TherapeuticArea | OncologicalDisorders |
| Use | AnHDACinhibitorreportedtoinhibithumanmultiplemyelomacelllines |
| MDLNumber | MFCD09833242 |
|---|---|
| ChemACX | X1612494-6 |
| InChI | InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h4-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+ |
| SMILES | CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO |
