AG Scientific/Panobinostat/P-2380/5 mg
商品编号：
P-2380-5mg
品牌：
agscientific
市场价：
¥6936.00
美元价：
4161.60
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The ICvalues of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.230.06, 28329, 754, 475 and 8912 nM, respectively. And to A2780 proliferation, ICvalue is 4.61.8 nM.
Additional Information
| Synonyms | LBH589, LBN-589, NVP-LBH590 |
|---|---|
| Product # | P-2380 |
| CAS # | 404950-80-7 |
| Chemical Name | (E)-N-HYDROXY-3-[4-[[2-(2-METHYL-1H-INDOL-3-YL)ETHYLAMINO]METHYL]PHENYL]PROP-2-ENAMIDE |
| Formula | C21H23N3O2 |
| MW | 349.43 |
| Appearance | Crystalline Solid |
| Purity | 99% by HPLC |
| Solubility | DMSO |
| Melting Point | 115 °C |
| Storage Temp | -20°C |
| Therapeutic Area | Oncological Disorders |
| Use | An HDAC inhibitor reported to inhibit human multiple myeloma cell lines |
Additional Information
| MDL Number | MFCD09833242 |
|---|---|
| ChemACX | X1612494-6 |
| InChI | InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h4-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+ |
| SMILES | CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO |
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
