AG Scientific/Kigamicin C/K-2023/0.5 mg
商品编号：
K-2023-0.5mg
品牌：
agscientific
市场价：
¥7107.80
美元价：
4264.68
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
*PleaseinquiretheavailABIlityforthisproduct.KigamicinCwasdiscoveredbyananti-austeritystrategy,targetingcancercells"tolerancetostarvation.ItselectivelykillsPANC-1cells(apancreaticcellline)atconcentrations100timeslowerundernutrientstarvedconditionsthaninnormalconditions.ThemechanismofactionisproposedtobeviablockadeofaPKB/Aktactivation,causedbythewithdrawalofnutrients.Itisactiveinvivoagainstahumanpancreaticcancerxenograftmodel.KigamicinCalsoinhibitsthegrowthofGrampositivebacteriaincludingMRSA,butisnotactiveagainstGramnegativebacteria.
AdditionalInformation
| Product# | K-2023 |
|---|---|
| CAS# | 680571-51-1 |
| Formula | C41H47NO16 |
| MW | 809.8 |
| Appearance | Paleyellowpowder |
| Purity | >98%byHPLC |
| Solubility | Solubleinethanol,methanol,DMSO,andDMF |
| StorageTemp | -20°C |
| TherapeuticArea | OncologicalDisorders |
| Use | KigamicinCandotherkigamicinsdemonstratecytotoxicityagainstPANC-1pancreaticcancercells |
| MDLNumber | MFCD09954098 |
|---|---|
| InChI | InChI=1S/C41H47NO16/c1-15-20(56-25-12-22(50-4)32(44)16(2)55-25)5-6-24(54-15)57-23-11-19(43)28-35(47)31-36(48)30-26-17(9-18-13-41(3)42(7-8-53-41)40(49)27(18)34(26)46)10-21-29(30)38(52-14-51-21)39(31)58-37(28)33(23)45/h9,15-16,19-25,32-33,43-46,48H,5-8,10-14H2,1-4H3/t15-,16-,19+,20+,21-,22-,23-,24+,25+,32-,33+,41-/m1/s1 |
| SMILES | O=C3N1[C@@](OCC1)(C)Cc2cc5c(c(O)c23)c7c4c(OCO[C@@H]4C5)c6O/C%10=C(C(=O)c6c7O)[C@@H](O)C[C@@H](O[C@@H]9O[C@H](C)[C@@H](O[C@@H]8O[C@H](C)[C@@H](O)[C@H](OC)C8)CC9)[C@@H]%10O |
