AG Scientific/GSK-J4, JMJ H3K27 Demethylase inhibitor (Cell Permeable)/G-2643/25 mg
商品编号：
G-2643-25mg
品牌：
agscientific
市场价：
¥6000.00
美元价：
3600.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (cat.# 10-1393). GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.
Additional Information
| Product # | G-2643 |
|---|---|
| CAS # | 1373423-53-0 |
| Chemical Name | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester |
| Formula | C24H27N5O2 |
| MW | 417.48 |
| Appearance | Yellow waxy solid |
| Purity | 99% by TLC NMR (Conforms) |
| Solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml). |
| Storage Temp | -20° |
Additional Information
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
