AG Scientific/Gliotoxin/G-2521/1 mg
商品编号：
G-2521-1mg
品牌：
agscientific
市场价：
¥2070.00
美元价：
1552.50
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
*PleaseinquiretheavailABIlityforthisproduct.GliotoxinisapotentepithiodioxopiperazinemycotoxinproducedbyspeciesofGlioclADIum,AspergillusandPenicillium.Atthecellularlevelgliotoxininhibitsabroadrangeofunrelatedmechanisms,includinginhibitionofchymotrypsin-likeactivityofthe20SproteasomeandCa2+releasefrommitochondria,activationoftranscriptionfactorNF-αºBinresponsetoavarietyofstimuliinTandBcells,anti-inflammatoryactivity,andinhibitionoffarnesyltransferaseandgeranylgeranyltransferase.Themodeofactionappearstobeviacovalentinteractionwithproteinsthroughmixeddisulphideformation.Gliotoxininhibitsanumberofthiol-requiringenzymesandalsodisplaysantioxidantandimmunomodulatoryactivity.
AdditionalInformation
| Synonyms | Aspergillin,SN12879,SN12870 |
|---|---|
| Product# | G-2521 |
| CAS# | 67-99-2 |
| Formula | C13H14N2O4S2 |
| MW | 326 |
| Appearance | Whitepowder |
| Purity | >99%byHPLC |
| Solubility | SolubleinDMSO(10mg/ml),methanol(10mg/ml),chloroform(10mg/ml),DMF,andPyridine |
| BoilingPoint | 699.72°Cat760mmHg |
| StorageTemp | 4°C |
| Use | AtoxicepipolythiodioxopiperazinemetabolitethatinducesapoptosisandinhibitsNF-kB |
| MDLNumber | MFCD00058534 |
|---|---|
| InChI | InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h4-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1 |
| SMILES | CN1C(=O)[C@]23CC4=CC=C[C@@H]([C@H]4N2C(=O)[C@]1(SS3)CO)O |
