AG Scientific/E-64D/E-2401/1 mg
商品编号：
E-2401-1mg
品牌：
agscientific
市场价：
¥1594.80
美元价：
1196.10
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AnirreversIBLe,highlyselectivecysteineproteaseinhibitorandcellpermeableanalogofE-64D.SpecificallyE-64Disan irreversiblecathepsinLandBinhibitor.
Mostrecentlye-64D,apan-cysteinecathepsininhibitorplaysanimportantroleinEbolavirus(EBOV)progressionbypreventingentrybyfiloviruses,especiallyEBOV.E-64dhasbeenshowntoleadtotheaccumulationofCTFsandAICDwithnochangeingammaandbetasecretaseactivities.Additionally,utilizingE-64dhasshownresultsinaccumulationofautophagicbodiesinsidevacuolesinArABIdopsisrootcells.
AdditionalInformation
| Synonyms | E-64D,E64d |
|---|---|
| Product# | E-2401 |
| CAS# | 88321-09-9 |
| Formula | C17H30N2O5 |
| MW | 342.433 |
| Appearance | Solid |
| Solubility | Solubleinethanol(>10mg/ml),DMSO(20mg/ml),DMF(30mg/ml),and1:1DMSO:PBS(pH7.2)(~0.5mg/ml).Insolubleinwater |
| TherapeuticArea | NeurologicalDisorders |
| Use | Thecysteineproteaseinhibitor,E64d,reducesbrainamyloid-βandimprovesmemorydeficitsinAlzheimer"sdiseasebyinhibitingcathepsinB,butnotBACE1,β-secretaseactivity |
| MDLNumber | MFCD00132883 |
|---|---|
| ChemACX | X1061801-0 |
| InChI | InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1 |
| SMILES | CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C |
