AG科学/Thapsigargin/T-1014-
商品编号：
T-1014-
品牌：
agscientific
市场价：
¥100.00
美元价：
75.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
Thaps; TG
SKU
T-1014
CAS #
67526-95-8
Chemical Name
[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
Chemical Formula
C34H50O12
Molecular Weight
650.8 Da
Appearance
White to off-white lyophilized powder
Purity
≥95% (HPLC)
Solubility
Clear and colorless solution at 10 mg/mL of CH3CN
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Oncological Disorders
USE
Thapsigargin is a tumor promoter and induces the release of intracellular stored calcium without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase. It blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin, and induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations. It may be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of protein kinase C activation.
Merck Index
Merck Index: 13.9342
MDL NUMBER
MFCD00083511
CHEMACX
X1096797-0
INCHI
IXFPJGBNCFXKPI-FSIHEZPISA-N
SMILES
CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
UN #'S
UN 2811
PACKING GROUP
II
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
msds 1
T-1014, Thapsigargin,SDS, diamond format.pdf
Certificate of Analysis 1
T-1014, H1380D.pdf
Certificate of Analysis 2
T-1014, H1380C.pdf
Certificate of Analysis 3
T-1014, H1380B.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
