AG科学/PUGNAc/P-2947-
商品编号：
P-2947-
品牌：
agscientific
市场价：
¥200.00
美元价：
150.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
Nac-lapco; O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
SKU
P-2947
CAS #
132489-69-1
Chemical Name
[(Z)-[(3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-ylidene]amino] N-phenylcarbamate
Chemical Formula
C15H19N3O7
Molecular Weight
353.33 Da
Appearance
White to off-white powder
Purity
≥ 97% (HPLC)
Solubility
May be dissolved in DMSO (35 mg/mL)
Storage Temp
-20°C
THERAPEUTIC AREA
Endocrine Disorders
USE
(Z)-Pugnac is an inhibitor of NCOAT (O-GlcNAcase), an enzyme which removes the N-acetylglucosamine moieties from 2-acetamido-2-deoxy-β-D-glucopyranose (O-GlcNAc) bound to proteins that were modified by O-GlcNAc. In addition, studies show that (Z)-Pugnac is the more potent inhibitor of O-GlcNAcase than its stereoisomer since it readily undergoes Beckmann rearrangement. Furthermore, (Z)-Pugnac increases the modification of proteins by GlcNAc in adipocytes and decreases insulin-stimulated 2-deoxyglucose (2DG) uptake and GLUT4 translocation in adipocytes, which implies that (Z)-Pugnac promotes insulin resistance in adipocytes. (Z)-Pugnac is an inhibitor of HEXA and HEXB.
Handling
Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required. Use with local exhaust ventilation. Do not breathe dust/fume/gas/mist/vapors/spray. Handle in accordance with good industrial hygiene andsafety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
msds 1
P-2947, PUGNAC, SDS, diamond format.pdf
Certificate of Analysis 1
P-2947, J1070.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
