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AG Scientific/CBR-5884, PHGDH / serine biosynthesis inhibitor/C-2901/5 mg
AG Scientific/CBR-5884, PHGDH / serine biosynthesis inhibitor/C-2901/5 mg
商品编号：
C-2901-5mg
品牌：
agscientific
市场价：
¥1500.00
美元价：
1125.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
CBR-5884 is a potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM. The action of PHGDH is the first committed step of serine biosynthesis and certain cancer cells overexpress PHGDH. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase, and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents.
Additional Information
| Synonyms | PHGDH / serine biosynthesis inhibitor |
|---|---|
| Product # | C-2901 |
| CAS # | 681159-27-3 |
| Chemical Name | Ethyl-5-(furan-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate |
| Formula | C14H12N2O4S2 |
Additional Information
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
