AG Scientific/Mycalolide B/M-1171-
商品编号：
M-1171-
品牌：
agscientific
市场价：
¥400.00
美元价：
300.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C
SKU
M-1171
CAS #
122752-21-0
Chemical Name
[(E,3R,4R,5S,6R,9S,10S)-4-acetyloxy-1-[formyl(methyl)amino]-11-[(10S,11R,13E,16S,20S,21R,22S,24E)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-1(28),2(31),4,6(30),8,13,24,
Chemical Formula
C52H74N4O17
Molecular Weight
1027.2 Da
Appearance
Colorless lyophilized wax
Purity
≥98%
Solubility
DMSO (20 mg/mL) or water (2 mg/mL)
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Available
USE
Mycalolide B has been shown to inhibit actin polymerization (IC50=10-50 nM) with a different mechanism of action from cytochalasin D. It suppresses actin-activated myosin Mg2+-ATPase activity without changing myosin light chain phosphorylation resulting in inhibition of smooth muscle contractions. Mycalolide B depolymerizes F-actin at differing concentrations by nibbling and forms a 1:1 complex with G-actin. Mycalolide B, at a concentration of 3 μM, abolished both ADP (10 μM)- and collagen (3 μg/ml)-induced platelet aggregation in vitro.
Merck Index
N/A
RTECS
N/A
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using thisproduct. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
M-1171, J1292.pdf
Certificate of Analysis 2
M-1171, J1253.pdf
Certificate of Analysis 3
M-1171, F1091.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
