AG Scientific/E-64/E-2030-
商品编号：
E-2030-
品牌：
agscientific
市场价：
¥500.00
美元价：
375.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
Thiol protease inhibitor
SKU
E-2030
CAS #
66701-25-5
Chemical Name
(2S,3S)-3-[[(2S)-1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
Chemical Formula
C15H27N5O5
Molecular Weight
357.4 Da
Appearance
White powder
Purity
≥99%
Solubility
Up to 20mg/ml in water, Up to 25mg/ml in DMSO
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
N/A
USE
E-64 is a broad spectrum cysteine proteinase and calpain activation inhibitor. E-64 has been reported to inhibit intracellular cathepsin B, cathepsin L, cathepsin H, Bax protease activity, and reduces oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP acitivity. Additionally, Prevotella intermedia studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S.
Merck Index
N/A
MDL NUMBER
MFCD00080261
CHEMACX
X1036521-8
PubChecm ID
123985
INCHI
LTLYEAJONXGNFG-DCAQKATOSA-N
SMILES
CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O
RTECS
RR0390000
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Citations
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junctionVivian W. Tang and William M. BrieherJ. Cell Biol., Jan 2012; 196: 115 - 130.
Citations_Hyperlink
http://jcb.rupress.org/cgi/reprint/196/1/115
msds 1
E-2030, E-64, SDS, diamond format.pdf
Certificate of Analysis 1
E-2030, J1210.pdf
Certificate of Analysis 2
E-2030, J1209.pdf
Certificate of Analysis 3
E-2030, J1060.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
