Wartmannin; Penicillium wortmanni; KY 12420; SL-2052

W-1022

19545-26-7

[(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate

C₂₃H₂₄O₈

428.4 Da

White powder with yellow cast

>98% by HPLC

DMSO (50 mg/ml), ethanol (25 mg/ml), methanol, 1:8 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~14 mg/ml)

240°C

N/A

-20°C, desiccated

Infectious Diseases

Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It is a selective, irreversible inhibitor of phosphatidylinositol 3-kinase (PI3K), and PI3K is involved in Toll-like receptor (TLR) signaling. Inhibition of PI3K with wortmannin enhances TLR-mediated inducible nitric-oxide synthase (iNOS) expression, activates NF-κB and up-regulates cytokine mRNA production. Furthermore, PI3K is required for autophagy, which is a complex pathway in which cell material can be sequestered and delivered to the lysosome for degradation. Inhibition of PI3K with wortmannin can inhibit autophagic sequestration.

13.10110.2001

MFCD00133927

X1097086-6

InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@@]4(c5c(coc5C3=O)C(=O)O[C@@H]4COC)C)C

CB9641000

UN 3462

I

WARNING! Very TOXICPROTECT FROM LIGHT & MOISTURE! Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.

W-1022, Wortmannin, SDS, diamond format.pdf

W-1022_W-1022,_D1029.pdf

W-1022_W-1022,_B1901.pdf

W-1022_W-1022,_B1828.pdf