AG Scientific/Carfilzomib/C-2857/5 mg
商品编号：
C-2857-5mg
品牌：
agscientific
市场价：
¥1137.40
美元价：
853.05
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ApotentandirreversIBLeproteasomeinhibitor.Syntheticanalogofthemicrobialproductepoxomcin.Comparedtobortezomibitdisplaysequalpotencybutgreaterselectivityforthechymotrypsin-likeactivityoftheproteasome.Incellcultureitismorecytotoxicthanbortezomibandhematologictumorcellsexhibitgreatersensitivitythansolidtumorcells.Treatmentofcellswithcarfilzomibresultsintheaccumulationofproteasomesubstratesandinductionofcellcyclearrestand/orapoptosis.Effectiveagainstmultiplemyeloma.Activeinvivo.
References:
1.MKBennettandCJKirkCurr.Opin.DrugDisc.Dev.200811:616
2.MHanadaetal.J.Antibiot.(Tokyo)199245:1746
3.SDDemoetal.CancerRes.200767:63834.DJKuhnetal.Blood2007110:3281
Notforhumantherapeuticuseorformedicinalpurposes.Forresearchapplicationsonly.
AdditionalInformation
| Synonyms | (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzeNEButanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-Phenylalaninamide;PR-171 |
|---|---|
| Product# | C-2857 |
| CAS# | 868540-17-4 |
| Formula | C40H57N5O7 |
| MW | 719.9 |
| Appearance | Whitepowder |
| Purity | >98%(HPLC) |
| Solubility | MaybedissolvedinDMSO(80mg/ml);orethanol(25mg/ml) |
| StorageTemp | -20°C |
