AG Scientific/Mithramycin A, Streptomyces plicatus/M-1072-
商品编号：
M-1072-
品牌：
agscientific
市场价：
¥100.00
美元价：
75.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
Plicamycin; Aureolic acid; Mitramycin; MA
SKU
M-1072
CAS #
18378-89-7
Chemical Name
(2S,3S)-2-[(2S,4R,5R,6R)-4-[(2S,4R,5S,6R)-4-[(2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-3-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-6-[(2S,4R,5R,6R)-4-[(2S,4R,5S,6R)-4,5-dih
Chemical Formula
C52H76O24
Molecular Weight
1085.0 Da
Appearance
Yellow Solid
Purity
98%
Solubility
DMSO: clear yellow solution at 100 mg/mL
Melting Point
180-183°C
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cells.
Merck Index
Merck Index: 12.7696.1996
MDL NUMBER
MFCD00135618
CHEMACX
X1009161-5
INCHI
InChI=1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27?,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43+,44-,45-,49+,50+,51-,52+/m1/s1
SMILES
Cc1c(cc2cc3c(c(c2c1O)O)C(=O)[C@H](C(C3)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]4C[C@H]([C@@H]([C@H](O4)C)O)O[C@H]5C[C@H]([C@@H]([C@H](O5)C)O)O[C@H]6C[C@]([C@@H]([C@H](O6)C)O)(C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@H]([C@@H]([C@H](O8)C)O)O
Peptide sequence
Not Applicable
RTECS
PZ2800000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin and eyes. Do not breathe dust. Do not breathe vapors or spray mist. Use only in area provided with appropriate exhaust ventilation.
Citations
Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cellsAparajita Das, Sunil Acharya, Koteswara Rao Gottipati, James B. McKnight, Hemakumar Chandru, Joseph L. Alcorn, and Vijay BoggaramAm J Physiol Lung Cell Mol Physiol, Oct 2011; 301: L427 - L440.
Citations_Hyperlink
http://ajplung.physiology.org/cgi/reprint/301/4/L427
Certificate of Analysis 1
M-1072, F1242C.pdf
Certificate of Analysis 2
M-1072, F1242B.pdf
Certificate of Analysis 3
M-1072, F1242A.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
