Geneticin; Glycoside-418 Sulfate

G-1033

108321-42-2

(2S,3S,4S,5S)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(1-hydroxyethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid

C₂₀H₄₀O₁₀N₄ • 2H₂SO₄

692.7 Da

White to off-white powder

≥90% (HPLC)

Soluble in water: 100mg/ml, colorless solution

N/A

N/A

Store at +4°C

Bacterial infections

Geneticin (G418) Sulfate is an aminoglycoside antibiotic that has originally been derived from Micromonospora rhodoranga NRRL 5326. This compound has been shown to cause a bypass of nonsense mutations during translation. Experiments have shown that geneticin sulfate inhibits the incorporation of amino acids into protein and can destroy fibroblasts. Mechanistic studies suggest that this agent affects the 80S ribosome and inhibits the elongation cycle. Further studies report that geneticin sulfate is highly active against amoebae, protozoa, tapeworm, and pinworm exposed murine cells.

N/A

CB9378500

Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. Protect from light and moisture! Warning: Harmful! Irritant!

G-1033, G-418 . sulfate, SDS, diamond format.pdf

G-1033, J1252A.pdf

G-1033, J1252.pdf

G-1033, J1241.pdf