AG Scientific/Rapamycin/R-1018-
商品编号：
R-1018-
品牌：
agscientific
市场价：
¥500.00
美元价：
375.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MoreInformation
AlternateName/Synonyms
Sirolimus;Rapamune;Sirolimusum
SKU
R-1018
CAS#
53123-88-9
ChemicalName
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetra
ChemicalFormula
C51H79NO13
MolecularWeight
914.2Da
Appearance
Whitepowder
Purity
≥99%
Solubility
Clearcolorlesssolutionat50mg/mLinEthanolorDMSO
MeltingPoint
183-184°C
Preparation
N/A
StorageTemp
-20°C
THERAPEUTICAREA
AutoimmuneDiseases;InfectiousDiseases
USE
RapamycinisamemberofthemacrolideimmunosuppressantfamilyandaFRAPinhibitor.RapamycinexhibitsbindingandinhibitoryactionstotheFK506bindingprotein(FKBP5)prolinerotamaseviasimultaneousbindingbyFKBP12andFRAP.FRAP(RAFT1)proteinsexhibithomologytoPI4-andPI3-kinases,whichhavePI4-kinaseandautophosphorylatingactivities.Therapamycin/FKBPcomplexdoesnotinhibittheFRAPPI4-kinaseactivity,butdoesinhibitFRAPautophosphorylation.RapamycinisuniqueinitsABIlitytoinhibitlymphokineinducedcellproliferationattheG1andSphaseaswellasanirreversIBLecellulararrestattheG1phaseinS.cerevisiaecells.ItalsoexhibitsselectivesignalblockingleADIngtotheactivationofp70/85S6kinase,whichispotentiallyduetotheinhibitionofFRAPautophosphorylationorproteinkinaseactivity.Angiogenesisinhibitionisalsoexhibited,possiblythroughtheinhibitionoftheAktpathway.RapamycinisaninhibitorofmTOR.
MerckIndex
13.8202.2001
MDLNUMBER
MFCD00867594
CHEMACX
X1000584-2
INCHI
InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
SMILES
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
RTECS
VE6250000
Handling
Corrosivehazard.Wearprotectivegloves/clothingandeye/faceprotection.Handleinaccordancewithgoodindustrialhygieneandsafetypractice.
CertificateofAnalysis1
R-1018,E1381J.pdf
CertificateofAnalysis2
R-1018,E1381H.pdf
CertificateofAnalysis3
R-1018,E1381G.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
