AG Scientific/Bongkrekic Acid/B-1053-
商品编号：
B-1053-
品牌：
agscientific
市场价：
¥2000.00
美元价：
1500.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
Bongkrekate; Bongkreksaure; Flavotoxin A; heptaenedioic acid; Bongkrekic acid triammonium salt; Bongkrekic acid (ammonium salt); 3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic acid, triammonium salt
SKU
B-1053
CAS #
11076-19-0
Chemical Name
(2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid
Chemical Formula
C28H38O7•3NH3
Molecular Weight
537.7 Da
Appearance
Lyophilized solid
Purity
≥98%
Solubility
Soluble in DMSO. Dilute with destilled water or buffer, pH 7.0-7.5
Melting Point
50-60°C
Preparation
Reconstitute to 1 mg/ml with distilled water
Storage Temp
-20°C
THERAPEUTIC AREA
Not Applicable
USE
Bongkrekic acid is an antiapoptotic agent. (1) This compound protects against NMDA receptor induced neuronal apoptosis (2) It extends cell survival in cells undergoing apoptosis following infection with viral vectors and abrogated apoptosis induced by hydrogen peroxide in T-cells. (3) Bongkrekic acid is an inhibitor of adenine nucleotide translocase, which is a component of the Mitochondrial Permeability Transition (MPT) pore complex. Thus, it prevents mitochondrial depolarization, swelling, rupture of mitochondria outer membrane, and release of apoptogenic proteins such as Cytochrome c.
Merck Index
13.1323.2001
RTECS
N/A
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required.Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray.Do not eat, drink or smoke when using this product.
Citations
Apoptotic Action of Peroxisome Proliferator-Activated Receptor-Activation in Human Non–Small-Cell Lung Cancer Is Mediated via Proline Oxidase-Induced Reactive Oxygen Species FormationKi Young Kim, Jin Hee Ahn, and Hyae Gyeong CheonMol. Pharmacol., Sep 2007; 72: 674 - 685.
Citations_Hyperlink
http://molpharm.aspetjournals.org/cgi/reprint/72/3/674
Certificate of Analysis 1
B-1053, J1203.pdf
Certificate of Analysis 2
B-1053, H1034B.pdf
Certificate of Analysis 3
B-1053, H1034A.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
