AG Scientific/17-AAG/A-1256-
商品编号：
A-1256-
品牌：
agscientific
市场价：
¥100.00
美元价：
75.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
Tanespimycin; 17-Allylaminogeldanamycin;
SKU
A-1256
CAS #
75747-14-7
Chemical Name
[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
Chemical Formula
C31H43N3O8
Molecular Weight
585.7 Da
Appearance
Purple Powder
Purity
>99%
Solubility
DMSO, Methanol: Clear purple solution at 10 mg/ml
Melting Point
207-208°C
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
For research use only. Not intended for diagnostic or therapeutic use. 17-AAG is a derivative of the antibiotic geldanamycin that is being studied in the treatment of cancer, specifically in younger patients with certain types of leukemia or solid tumors, especially kidney tumors. It works by inhibiting Hsp90, which is expressed in those tumors.
Merck Index
N/A
MDL NUMBER
MFCD04973892
CHEMACX
X1367336-8
INCHI
InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10-,20-15-/t17-,19+,24+,25+,27-,29+/m1/s1
SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C([C@@H]([C@H](/C=CC=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)/C)C)O)OC
RTECS
Not Applicable
UN #'S
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation
Citations
CLINICAL INVESTIGATIONS:Pharmacokinetic Assessment of the Uptake of 16β-18F-Fluoro-5-Dihydrotestosterone (FDHT) in Prostate Tumors as Measured by PETBradley J. Beattie, Peter M. Smith-Jones, Yuliya S. Jhanwar, Heiko Schöder, C. Ross Schmidtlein, Michael J. Morris, Pat Zanzonico, Olivia Squire, Gustavo S.P. Meirelles, Ron Finn, Mohammad Namavari, Shangde Cai, Howard I. Scher, Steven M. Larson, and John L. HummJ. Nucl. Med., Feb 2010; 51: 183 - 192.
Citations_Hyperlink
http://jnm.snmjournals.org/content/51/2/183.full.pdf+html
msds 1
A-1256, 17-AAG, SDS, diamond format.pdf
Certificate of Analysis 1
A-1256, E1348H.pdf
Certificate of Analysis 2
A-1256, E1348G.pdf
Certificate of Analysis 3
A-1256, E1348F.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
