CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively-spliced variants encoding distinct proteins have been reported, and two are related, named p16-INK4 and p14 respetively, sharing 50% identity. The third one is completely stuctually un-related, called p14 (ARF) or p19 (ARF). P16-INK4A reacted with p16 specifically. P16 plays an important role in regulating the cell cycle, and mutations in p16 increase the risk of developing a variety of cancers, notably melanoma.||Applications: |Suitable for use in ELISA, Western Blot, Immunofluorescence, Immunoprecipitation, Immunohistochemistry, Flow Cytometry. Other applications not tested.||Recommended Dilution:|Western Blot: 1:500-1:5000|Immunoprecipitation: 1:500-1:5000|Immunohistochemistry: 1:50-1:500|Immunofluorescence: 1:20-1:200|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.Product Type:Pab|Isotype: IgG|Host: rabbit|Concentration: ~1mg/ml|Form: Supplied as a liquid in PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |Purity: Purified by immunoaffinity chromatography.|Immunogen: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)|Specificity: Recognizes P16-INK4A. Species Crossreactivity: human, mouse, rat||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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