AG Scientific/Bisindolylmaleimide V/1 mg/B-1291-1 mg
商品编号：
B-1291-1mg
品牌：
agscientific
市场价：
¥4500.00
美元价：
3375.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MoreInformation
AlternateName/Synonyms
Bongkrekate;Bongkreksaure;FlavotoxinA;heptaenedioicacid;Bongkrekicacidtriammoniumsalt;Bongkrekicacid(ammoniumsalt);3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioicacid,triammoniumsalt
SKU
B-1053
CAS#
11076-19-0
ChemicalName
(2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioicacid
ChemicalFormula
C28H38O7•3NH3
MolecularWeight
537.7Da
Appearance
Lyophilizedsolid
Purity
≥98%
Solubility
SolubleinDMSO.Dilutewithdestilledwaterorbuffer,pH7.0-7.5
MeltingPoint
50-60°C
Preparation
Reconstituteto1mg/mlwithdistilledwater
StorageTemp
-20°C
THERAPEUTICAREA
NotApplicable
USE
Bongkrekicacidisanantiapoptoticagent.(1)ThiscompoundprotectsagainstNMDAreceptorinducedneuronalapoptosis(2)ItextendscellsurvivalincellsundergoingapoptosisfollowinginfectionwithviralvectorsandabrogatedapoptosisinducedbyhydrogenperoxideinT-cells.(3)Bongkrekicacidisaninhibitorofadeninenucleotidetranslocase,whichisacomponentoftheMitochondrialPermeABIlityTransition(MPT)porecomplex.Thus,itpreventsmitochondrialdepolarization,swelling,ruptureofmitochondriaoutermembrane,andreleaseofapoptogenicproteinssuchasCytochromec.
MerckIndex
13.1323.2001
RTECS
N/A
Handling
Avoidcontactwithskin,eyesorclothing.Usepersonalprotectiveequipmentasrequired.Washcontaminatedclothingbeforereuse.Donotbreathedust/fume/gas/mist/vapors/spray.Donoteat,drinkorsmokewhenusingthisproduct.
Citations
ApoptoticActionofPeroxisomeProliferator-ActivatedReceptor-ActivationinHumanNon–Small-CellLungCancerIsMediatedviaProlineOxidase-InducedReactiveOxygenSpeciesFormationKiYoungKim,JinHeeAhn,andHyaeGyeongCheonMol.Pharmacol.,Sep2007;72:674-685.
Citations_Hyperlink
http://molpharm.aspetjournals.org/cgi/reprint/72/3/674
CertificateofAnalysis1
B-1053,J1203.pdf
CertificateofAnalysis2
B-1053,H1034B.pdf
CertificateofAnalysis3
B-1053,H1034A.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
