AG Scientific/（+/-）-博来司他丁/5 mg/B-1289-5 mg
商品编号：
B-1289-5mg
品牌：
agscientific
市场价：
¥2620.00
美元价：
1965.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
ZK-62711
SKU
R-1012
CAS #
61413-54-5
Chemical Name
4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Chemical Formula
C16H21NO3
Molecular Weight
275.4 Da
Appearance
White solid
Purity
≥98%
Solubility
Soluble in Water
Melting Point
132°C
Preparation
N/A
Storage Temp
4°C, desiccated
THERAPEUTIC AREA
Neurodegenrative Diseases
USE
Rolipram is a selective, cell-permeable inhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC50=1 μM). This compound has been shown to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile response. Rolipram promotes apoptosis in HL60 cells through a cAMP-independent mechanism and has been shown to enhance neuronal survival. Rolipram is an inhibitor of PDE4A1 and PDE4B.
Merck Index
13.8332.2001
MDL NUMBER
MFCD00270906
CHEMACX
X1038250-2
INCHI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
SMILES
COc1ccc(cc1OC2CCCC2)C3CC(=O)NC3
RTECS
UY5749237
Handling
Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.
Citations
BEHAVIORAL/SYSTEMS/COGNITIVE:Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP SignalingYun-Feng Li, Yu-Fang Cheng, Ying Huang, Marco Conti, Steven P. Wilson, James M. O'Donnell, and Han-Ting ZhangJ. Neurosci., Jan 2011; 31: 172 - 183.
Citations_Hyperlink
http://www.jneurosci.org/cgi/reprint/31/1/172
msds 1
R-1012, Rolipram, SDS, diamond format.pdf
Certificate of Analysis 1
R-1012, F1254E.pdf
Certificate of Analysis 2
R-1012, F1254D.pdf
Certificate of Analysis 3
R-1012, F1254C.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
