AG Scientific/AS-8351/K-2567/5 mg
商品编号：
K-2567-5mg
品牌：
agscientific
市场价：
¥1876.40
美元价：
1407.30
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.
References:
1. N Cao et al. Science 2016 352:1216
Additional Information
| Synonyms | 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone, NSC-51355, |
|---|---|
| Product # | K-2567 |
| CAS # | 796-42-9 |
| Formula | C17H13N3O2 |
| MW | 291.3 |
| Appearance | Yellow powder |
| Purity | >98% |
| Solubility | May be dissolved in DMSO or ethanol or DMF |
| Melting Point | 262-264°C |
| Storage Temp | -20°C |
Additional Information
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
