Lectins are proteins or glycoproteins of non-immune origin that agglutinate cells and/or precipitate complex carbohydrates. Lectins are capable of binding glycoproteins even in presence of various detergents.Arachis hypogaea lectin or Peanut Agglutinin (PNA) is isolated from peanuts and purified by affinity chromatography. The lectin has a molecular weight of 110 kDa and consists of four identical subunits of approximately 27 kDa each. PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. Lectin PNA is specific for terminal β-galactose and binds preferentially to a commonly occurring structure, galactosyl (β-1,3) N-acetylgalactosamine. PNA has potent anti-T activity similar to the anti-T antibody in human sera. PNA has been used in tumour tissue determination for transitional mucosa malignancies. The lectin also agglutinates neuraminidase-treated human erythrocytes at <0.1 µg/ml="" after="" trypsin="" treatment="" of="" cells="" and="" its="" activity="" is="" inhibited="" by="" lactose="" and="" galactose.="" though="" pna="" does="" not="" require="" any="" divalent="" cations="" for="" activity,="" the="" presence="" of="" calcium="" ions="" in="" diluents="" can="" enhance="" the="" binding="" of="" pna="" to="" receptors,="" possibly="" by="" neutralizing="" the="" negative="" charges="" on="" sialic="" acid="" residues="" adjacent="" to="" the="" receptor="" sequence.="" pna="" is="" useful="" in="" distinguishing="" between="" normal="" and="" tumor="" tissues="" and="" in="" assessing="" malignancy="" in="" transitional="" mucosa.="" in="" addition,="" pna="" binding="" can="" be="" used="" to="" measure="" cellular="" maturity="" in="" lymphoid="" tissues,="" to="" distinguish="" a="" variety="" of="" lymphocyte="" subpopulations="" in="" man="" and="" experimental="" animals,="" and="" to="" measure="" the="" levels="" of="" lymphoid="" cell="" populations="" in="" many="" diseases.="" pna="" can="" be="" employed="" in="" the="" fractionation="" of="" stem="" cells="" in="" mice="" for="" use="" in="" bone="" marrow="" transplantation="" across="" histocompatibility="" barriers.="" pna="" is="" silica-coated="" super="" paramagnetic="" beads="" covalently="" linked="" to="" peanut="" agglutinin="" (pna).="" peanut="" agglutinin="" is="" a="" non-glycosylated="" lectin="" with="" a="" high="" binding="" affinity="" for="" the="" tumor="" associated="" thomsen-friedenreich="" antigen="" (“t`-antigen)="" and="" binds="" preferentially="" to="" galactosyl="" (α-1,3)="" n-acetylgalactosamine.="" presence="" of="" ca2+="" can="" enhance="" pna="" binding.="">

Additional Information

Product #	A-2909
Appearance	Liquid Suspension
Purity	High Purity Grade
Storage Temp	4°C
Use	PNA can be used in detection of relocalization of Tag antigen in large bowel carcinomaPNA can be used to distinguish between human lymphocyte subsets.PNA can be used as probe in histochemistry and immunohistochemistryPNA can be used in human erythrocyte/lymphocyte studiesTo investigate the changes related to cell differentiation.Agglutinates neuraminidase-treated human erythrocytes.PNA is useful in distinguishing between normal and tumor tissues and in assessing malignancy in transitional mucosa.To measure the levels of lymphoid cell populations in many diseases.

Additional Information

AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。