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当前位置: 首页 > 产品中心 > Other_reagents > AG Scientific/Arachis hypogaea(花生)凝集素(PNA)-FITC/A-2897/2 mg
商品详细AG Scientific/Arachis hypogaea(花生)凝集素(PNA)-FITC/A-2897/2 mg
AG Scientific/Arachis hypogaea(花生)凝集素(PNA)-FITC/A-2897/2 mg
AG Scientific/Arachis hypogaea(花生)凝集素(PNA)-FITC/A-2897/2 mg
商品编号: A-2897-2mg
品牌: agscientific
市场价: ¥2760.80
美元价: 2070.60
产地: 美国(厂家直采)
公司:
产品分类: 其他试剂
公司分类: Other_reagents
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Lectinsareproteinsorglycoproteinsofnon-immuneoriginthatagglutinatecellsand/orprecipitatecomplexcarbohydrates. Lectinsarecapableofbindingglycoproteinseveninpresenceofvariousdetergents.

Arachishypogaea lectinorPeanutAgglutinin(PNA)isisolatedfrompeanutsandpurifiedbyaffinitychromatography.Thelectinhasamolecularweightof110kDaandconsistsoffouridenticalsubunitsofapproximately27kDaeach. PNAdoesnotagglutinatenormalhumanerythrocytes,butstronglyagglutinatesneuraminidasetreatederythrocytes.LectinPNAisspecificforterminalβ-galactoseandbindspreferentiallytoacommonlyoccurringstructure,galactosyl(β-1,3)N-acetylgalactosamine.PNAhaspotentanti-Tactivitysimilartotheanti-Tantibodyinhumansera. PNAhasbeenusedintumourtissuedeterminationfortransitionalmucosamalignancies.Thelectinalsoagglutinatesneuraminidase-treatedhumanerythrocytesat<0.1µg/mlaftertrypsintreatmentofcellsanditsactivityisinhibitedbylactoseandgalactose. ThoughPNAdoesnotrequireanydivalentcationsforactivity,thepresenceofcalciumionsindiluentscanenhancethebindingofPNAtoreceptors,possIBLybyneutralizingthenegativechargesonsialicacidresiduesadjacenttothereceptorsequence.

PNAisusefulindistinguishingbetweennormalandtumortissuesandinassessingmalignancyintransitionalmucosa.Inaddition,PNAbindingcanbeusedtomeasurecellularmaturityinlymphoidtissues,todistinguishavarietyoflymphocytesubpopulationsinmanandexperimentalanimals,andtomeasurethelevelsoflymphoidcellpopulationsinmanydiseases.PNAcanbeemployedinthefractionationofstemcellsinmiceforuseinbonemarrowtransplantationacrosshistocompatibilitybarriers.

FluoresceinlabeledPeanutagglutininhasanappropriatenumberofFluorochromesboundtoprovidetheoptimumstainingcharacteristicsforthislectin.Thisconjugateissuppliedessentiallyfreeofunconjugatedfluorochromes. FITC-conjugatedPNAhasanexcitationat495nmandanemissionatabout515nm.  FluorescentConjugatesare extremely lightsensitive.

TechnicalSpecifications:

  • LigandSource: Arachishypogaea
  • MolecularWeight: 110kDa
  • CarbohydrateSpecificity: Galβ1,3GalNAc(T-antigen)
  • Inhibiting/ElutingSugar:Galactose
  • CarbohydrateforElution: 0.2MGalactose
  • BloodGroupSpecificity: Tantigen(M,N)
  • Conjugate:FITC
  • Form: Liquid
  • Isoelectric(pI): 5.5-6.5

AdditionalInformation

AdditionalInformation

SynonymsPeanutAgglutinin;PNA;Galactose-bindingLectin
Product#A-2897
AppearanceLiquid
PurityHighPurityGrade
StorageTemp-20°C
UseBiotynylatedPNAcanbeusedforthedetectionofrelocalizationofTagantigeninlargebowelcarcinomABIotynylatedPNAcanbeusedtodistinguishbetweenhumanlymphocytesubsets.BiotynylatedPNAcanbeusedasprobeinhistochemistryandimmuno-histochemistry.BiotynylatedPNAcanbeusedinhumanerythrocyte/lymphocytestudies.
品牌介绍
AG Scientific, Inc.成立于1997年,专注于创新生化制剂以及用于诊断测试开发的定制原材料,以推进临床前研究药物开发。产品涉及抗生素,生物洗涤剂,缓冲液,诊断,酶,医疗设备试剂,蛋白酶K,还原剂,RNase A等。