AG Scientific/FK506 (Tacrolimus)/5 mg/48.36
商品编号：
48.36
品牌：
agscientific
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MoreInformation
AlternateName/Synonyms
Prograf;Protopic;Fujimycin;Tsukubaenolide;Modigraf;Advagraf;Protopy;AstagrafXL
SKU
F-1030
CAS#
104987-11-3
ChemicalName
(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetron
ChemicalFormula
C44H69NO12
MolecularWeight
804.0Da
Appearance
Whitepowder
Purity
≥99%
Solubility
Clearandcolorlessat10mg/mlDMSOorEthanol
MeltingPoint
130-132°C
StorageTemp
-20°C
THERAPEUTICAREA
Immunotherapy
USE
Tacrolimus,alsoknownasfujimycinorFK506,isanimmunosuppressivedrugusedmainlyafterallogeneicorgantransplanttolowertheriskoforganrejection.Itachievesthisbyinhibitingtheproductionofinterleukin-2,amoleculethatpromotesthedevelopmentandproliferationofTcells,whicharevitaltothebody"slearned(oradaptive)immuneresponse.TacrolimusisalsousedinthetreatmentofotherTcell-mediateddiseasessuchaseczemaandpsoriasis.(forwhichitisappliedtotheskininamedicatedointment),severerefractoryuveitisafterbonemarrowtransplants,exacerbationsofminimalchangedisease,Kimura"sdisease,andtheskinconditionvitiligo.
MerckIndex
13.9117.2001
Handling
Avoidcontactwithskin,eyes,andpersonalclothing.Washhandsthoroughlyafterhandling.Avoidbreathingfumes.Useonlywithadequateventilation.Wearsuitableprotectiveclothing,gloves,andeye/faceprotection.Keepawayfromsourcesofignition.Minimizedustgenerationandaccumulation.Keepcontainertightlyclosed.Openandhandlecontainerwithcare.Donoteat,drink,orsmokewhilehandling.
MSDs1
F-1030,FK-506,SDS,diamondformat.pdf
CertificateofAnalysis1
F-1030,G1212A.pdf
CertificateofAnalysis2
F-1030,G1212.pdf
CertificateofAnalysis3
F-1030,F1198E.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
