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AG Scientific/(R,S)-Rolipram, Inhibitor of PDE IV/5 mg/41.66
AG Scientific/(R,S)-Rolipram, Inhibitor of PDE IV/5 mg/41.66
商品编号：
41.66
品牌：
agscientific
市场价：
¥0.00
美元价：
0.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MoreInformation
AlternateName/Synonyms
ZK-62711
SKU
R-1012
CAS#
61413-54-5
ChemicalName
4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
ChemicalFormula
C16H21NO3
MolecularWeight
275.4Da
Appearance
Whitesolid
Purity
≥98%
Solubility
SolubleinWater
MeltingPoint
132°C
Preparation
N/A
StorageTemp
4°C,desiccated
THERAPEUTICAREA
NeurodegenrativeDiseases
USE
Rolipramisaselective,cell-permeableinhibitorofcAMP-specificPDE(phosphodiesterase)(PDE4,IC50=1μM).ThiscompoundhasbeenshowntoinhibitPDE4activityinhumancavernosaltissue,whichinterruptsthesignaltransductionpathwayoferectileresponse.RoliprampromotesapoptosisinHL60cellsthroughacAMP-independentmechanismandhasbeenshowntoenhanceneuronalsurvival.RolipramisaninhibitorofPDE4A1andPDE4B.
MerckIndex
13.8332.2001
MDLNUMBER
MFCD00270906
CHEMACX
X1038250-2
INCHI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
SMILES
COc1ccc(cc1OC2CCCC2)C3CC(=O)NC3
RTECS
UY5749237
Handling
FurtherprocessingofsolidmaterialsmayresultintheformationofcombustIBLedusts.Thepotentialforcombustibledustformationshouldbetakenintoconsiderationbeforeadditionalprocessingoccurs.Provideappropriateexhaustventilationatplaceswheredustisformed.
Citations
BEHAVIORAL/SYSTEMS/COGNITIVE:Phosphodiesterase-4DKnock-OutandRNAInterference-MediatedKnock-DownEnhanceMemoryandIncreaseHippocampalNeurogenesisviaIncreasedcAMPSignalingYun-FengLi,Yu-FangCheng,YingHuang,MarcoConti,StevenP.Wilson,JamesM.O"Donnell,andHan-TingZhangJ.Neurosci.,Jan2011;31:172-183.
Citations_Hyperlink
http://www.jneurosci.org/cgi/reprint/31/1/172
MSDs1
R-1012,Rolipram,SDS,diamondformat.pdf
CertificateofAnalysis1
R-1012,F1254E.pdf
CertificateofAnalysis2
R-1012,F1254D.pdf
CertificateofAnalysis3
R-1012,F1254C.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
