AG Scientific/17-AAG/500 ug/41.54
商品编号:
41.54
品牌:
agscientific
市场价:
¥0.00
美元价:
0.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
AlternateName/Synonyms
Tanespimycin;17-Allylaminogeldanamycin;
SKU
A-1256
CAS#
75747-14-7
ChemicalName
[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azABIcyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl]carbamate
ChemicalFormula
C31H43N3O8
MolecularWeight
585.7Da
Appearance
PurplePowder
Purity
>99%
Solubility
DMSO,Methanol:Clearpurplesolutionat10mg/ml
MeltingPoint
207-208°C
Preparation
N/A
StorageTemp
-20°C
THERAPEUTICAREA
OncologicalDisorders
USE
Forresearchuseonly.Notintendedfordiagnosticortherapeuticuse.17-AAGisaderivativeoftheantibioticgeldanamycinthatisbeingstudiedinthetreatmentofcancer,specificallyinyoungerpatientswithcertaintypesofleukemiaorsolidtumors,especiallykidneytumors.ItworksbyinhibitingHsp90,whichisexpressedinthosetumors.
MerckIndex
N/A
MDLNUMBER
MFCD04973892
CHEMACX
X1367336-8
INCHI
InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10-,20-15-/t17-,19+,24+,25+,27-,29+/m1/s1
SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C([C@@H]([C@H](/C=CC=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)/C)C)O)OC
RTECS
NotApplicable
UN#"S
NotApplicable
Handling
Avoidcontactwithskin,eyesorclothing.Usepersonalprotectiveequipmentasrequired.Washcontaminatedclothingbeforereuse.Donotbreathedust/fume/gas/mist/vapors/spray.Donoteat,drinkorsmokewhenusingthisproduct.Usewithlocalexhaustventilation
Citations
CLINICALINVESTIGATIONS:PharmacokineticAssessmentoftheUptakeof16β-18F-Fluoro-5-Dihydrotestosterone(FDHT)inProstateTumorsasMeasuredbyPETBradleyJ.Beattie,PeterM.Smith-Jones,YuliyaS.Jhanwar,HeikoSchöder,C.RossSchmidtlein,MichaelJ.Morris,PatZanzonico,OliviaSquire,GustavoS.P.Meirelles,RonFinn,MohammadNamavari,ShangdeCai,HowardI.Scher,StevenM.Larson,andJohnL.HummJ.Nucl.Med.,Feb2010;51:183-192.
Citations_Hyperlink
http://jnm.snmjournals.org/content/51/2/183.full.pdf+html
MSDs1
A-1256,17-AAG,SDS,diamondformat.pdf
CertificateofAnalysis1
A-1256,E1348H.pdf
CertificateofAnalysis2
A-1256,E1348G.pdf
CertificateofAnalysis3
A-1256,E1348F.pdf
品牌介绍
AG Scientific, Inc.成立于1997年,专注于创新生化制剂以及用于诊断测试开发的定制原材料,以推进临床前研究药物开发。产品涉及抗生素,生物洗涤剂,缓冲液,诊断,酶,医疗设备试剂,蛋白酶K,还原剂,RNase A等。