AG Scientific/Mycophenolic Acid, MPA/M-1036/1 g
商品编号：
M-1036-1g
品牌：
agscientific
市场价：
¥7469.60
美元价：
4481.76
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Immunosuppressive agent. Mycophenolic acid (MPA) has been tested extensively in renal transplant patients and has been shown to be effective in reducing the incidence of acute graft rejection. MPA is now being evaluated in combinations with tacrolimus. It selectively inhibits lymphocyte proliferation by blocking the enzyme, inosine monophosphate dehydrogenase, part of in the guanosine monophosphate pathway.
This enzyme is involved in the de novo synthesis of purine nucleotides1.
1.) Methanol-Associated Matrix Effects in Electrospray Ionization Tandem Mass Spectrometry.Quantification of Mycophenolic Acid and Glucuronide Metabolite in Human Serum by HPLC-Tandem Mass Spectrometry.
Additional Information
| Synonyms | MPA, mycophenolate mofetil (MMF) |
|---|---|
| Product # | M-1036 |
| CAS # | 24280-93-1 |
| Chemical Name | 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid |
| Formula | C17H20O6 |
| MW | 320.3 |
| Appearance | White to off-white Powder |
| Purity | 98% |
| Solubility | Soluble in ethanol (>10 mg/ml), DMSO (20 mg/ml), DMF (30 mg/ml), and 1:1 DMSO:PBS (pH 7.2) (~0.5 mg/ml). Insoluble in water |
| Melting Point | 141°C |
| Boiling Point | 611.61 °C at 760 mmHg |
| Storage Temp | +4°C |
| Therapeutic Area | Autoimmune Diseases |
| Use | Mycophenolic acid is an immunosuppressant drug used to prevent rejection in organ transplantation |
Additional Information
| Merck Index | 13.6352.2001 |
|---|---|
| MDL Number | MFCD00036814 |
| ChemACX | X1002405-4 |
| InChI | InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19) |
| SMILES | Cc1c2c(c(c(c1OC)CC=C(C)CCC(=O)O)O)C(=O)OC2 |
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
