AG Scientific/JIB-04/J-2519/25 mg
商品编号：
J-2519-25mg
品牌：
agscientific
市场价：
¥6900.00
美元价：
4140.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
AnovelspecificinhibitoroftheJumonjifamilyofhistonedemethylasesinvitro,incancercellsandintumorsinvivo.IC50=230,340,435,445,855and1100nMforJARID1A,JMJD2E,JMJD2B,JMJD2A,JMJD3andJMJD2Crespectively. Reducestumorburdenandprolongslifeinamousemodel.SuppressestranslationinitiationandenhancesmTORinhibitorsensitivity.Inhibitsthegrowthoftemozolomide-resistantglioblastomacellsandcrossesthebloodbrainbarrier.
ArecentstudyhasshownthatJIB-04increasestheexpressionofPD-L1in SUM149-MAbreastcancercelllines.IncreasedPD-L1expressioninbreastcancercelllinesrendersthemresponsivetovarioustherapiesnotjustimmunecheckpointblockadeofPD-L1.HencetheseresultssuggestthatJIB-04isapotentialanti-canceragentthatcanhaltcancerprogressionandpreventresistancetotherapies.
AdditionalInformation
| Product# | J-2519 |
|---|---|
| CAS# | 199596-05-9 |
| ChemicalName | (E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine |
| Formula | C170H13CIN4 |
| MW | 308.8 |
| Appearance | yellowpowder |
| Purity | >98%(TLC);NMR(Conforms) |
| Solubility | MaybedissolvedinDMSO(30mg/ml) |
| StorageTemp | Storedesiccatedassuppliedat-20°Cforupto2years.Storesolutionsat-20°Cforupto2months. |
