AG Scientific/Thapsigargin，内质网应激诱导剂/T-1014/10 mg
商品编号：
T-1014-10mg
品牌：
agscientific
市场价：
¥7661.80
美元价：
4597.08
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Thapsigargin isaspecificinhibitorofthesarcoplasmic/endoplasmicreticulum Ca2+-ATPase (SERCA). Thapsigargin increasescytosolic calcium levelsthroughreleasefromintracellular calcium stores.DepletionofERcalciumstoresleadstoCa2+ influxviaactivationof store(voltage)-operatedcalciumchannels inthe plasmamembrane,mediatingnumerousphysiologicalfunctions,including exocytosis, chemotaxis,transcription, celldivision,and apoptosis. Therearepreclinicalindicationsthatthedrugmayhave anticancer potential.
Arecentpaperstatesthapsigarginisamoleculethatindirectly&robustlyinhibitsnonsense-mediatedRNAdecay(NMD)1byDr.Zheng,UCRinRNA(volume23,No.3, March2017).HestatestheyhavedevelopedamethodthatdetectsNMDefficiencyinsidethecell.
AdditionalInformation
| Synonyms | thaps,tg |
|---|---|
| Product# | T-1014 |
| CAS# | 67526-95-8 |
| ChemicalName | [(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-ACETYLOXY-4-BUTANOYLOXY-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(Z)-2-METHYLBUT-2-ENOYL]OXY-2-OXO-4,5,6A,7,8,9B-HEXAHYDROAZULENO[4,5-B]FURAN-7-YL]OCTANOATE |
| Formula | C34H50O12 |
| MW | 650.8 |
| Appearance | ClearColorlessFilm |
| Purity | 98% |
| Solubility | DMSO(~100mg/ml) |
| BoilingPoint | 691.9±55.0°Cat760mmHg |
| StorageTemp | -20°C |
| TherapeuticArea | OncologicalDisorders |
| Use | ItisatumorpromoterandinducesthereleaseofintracellularstoredCa2+withouthydrolysisofinositolphospholipidsviainhibitionofthesarco/endoplasmicreticulumCa2+-ATPase |
| MerckIndex | MerckIndex:13.9342 |
|---|---|
| MDLNumber | MFCD00083511 |
| ChemACX | X1096797-0 |
| InChI | InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1 |
| SMILES | CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=CC)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O |
