P32/98isacell-permeable,potentandselectiveinhibitorofdipeptidylpeptidaseIV(DPPIV)(Ki=130nM).Maybeusedincellculture(1-10mM)or invivo (10mg/Kgorally). IthasbeenhypothesizedthatchronicDPPIVinhibitortreatmentofdiabeticanimals,improvesglucosetolerance, enhancesβ-cellglucoseresponsiveness,replication,andturnover,andresultsinsustainedimprovementsinβ-cellfunction.
Aspreviouslystated,DPPIVinhibitorsareanewclassofanti-diabeticdrugs.HoweverDPPIVmetabolizestoatleast24endogenoussubstrates,thepharmacologicalconsequencesofinhibitingthemetabolismofmostofthesesubstratesisunknown.Research studieshaveshownthatDPPIVisexpressedintherenalmicrocirculationandinhibitionofthisectoenzymecausesarterialPYY1–36tomoreeffectivelyenhanceangiotensinII-inducedrenalvasoconstrictioningeneticallysusceptIBLekidneys.
Application:
P32/98isaspecific,competitivetransitionstatesubstrateanaloginhibitorofdipeptidylpeptidaseIV(DPP-IV,DPIV,CD26,CD-26).Usefulindiabetesresearch,aswellas,proteinpreservationstudies&transport.
AdditionalInformation
| Synonyms | DPPIV,DPP-IV,dipeptidylpeptidaseIV,CD26,CD-26 |
|---|---|
| Product# | P-1685 |
| CAS# | 136259-20-6 |
| ChemicalName | (2S,3S)-2-Amino-3–methyl-1-(thiazolidin-3-yl)pentan-1-onehemi-fumarate |
| Formula | C9H18N2OS.1/2C4H404 |
| MW | 260.4 |
| Appearance | Whitepowder |
| Purity | >98% |
| Solubility | Solubleinwater(20mg/ml)orDMSO(25mg/ml) |
| StorageTemp | -20°C,Keepdry.Shippedonblueice.Freezeuponarrival. |
| TherapeuticArea | Immunotherapy |
| Use | Usefulindiabetesresearch,aswellas,proteinpreservationstudies&transport. |
