AG Scientific/MG-132/M-1157/1 mg
商品编号：
M-1157-1mg
品牌：
agscientific
市场价：
¥320.20
美元价：
240.15
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MG-132isacellpermeablereversIBLeproteosomeinhibitor.MG-132isalsocalledas carbobenzoxy-L-leucyl-L-leucyl-L-leucinal,Z-LLL-CHO,isapeptidealdehyde,partofagroupofchemicalscapableofinhibitingproteases,suchasserineproteasesandcalpainetc.MG-132 reducesthedegradationofIκB(inhibitoryκB),GRK2(G-protein-receptorkinase2),ARC(apoptosisrepressorwithcaspaserecruitmentdomain),andHSP(heatshockproteins),allofwhichexertbeneficialeffectsonacutemyocardialischemia.ModerateproteasomeinhibitionbyMG132resultsintheupregulationofanti-oxidativeenzymes,anditprotectsratmyocytesagainstH2O2-mediatedoxidativestress.Italsoinhibits5-lipoxygenasethatselectivelydisruptsfunctionof c-MycincancercellsandNF- κBactivation.
AdditionalInformation
| Synonyms | Z-LLL-CHO |
|---|---|
| Product# | M-1157 |
| ChemicalName | Z-Leu-Leu-Leu-aldehyde;Z-LLL-CHO |
| Formula | C26H41N3O5 |
| MW | 475.6 |
| Appearance | WhitePowder |
| Purity | >95% |
| Solubility | SolubleinDMSO. |
| StorageTemp | -20°C |
| Use | UsedinProteosomeactivityassay. |
