AEBSFisabroadspectrum,watersoluble,irreversIBLeserineproteaseinhibitor.InhibitionconstantsaresimilartothoseofPMSFandDFP.AEBSFhasbeenshowntoinhibittrypsin,chymotrypsin,plasminkallikreinandthrombin.AsanalternativetoPMSFandDFP,AEBSFofferslowertoxicity,improvedsolubilityinwaterandimprovedstABIlityinaqueoussolutions.Ithasbeenshowntoinhibittheconstitutiveproductionofbetaamyloid(Abeta)infivedifferenthumancelllines,bothneuralandnon-neural.
AEBSFalsoinhibitsactivationofTGFβ(transforminggrowthfactorbeta),moderatelyinhibitsDipeptidylpeptidaseIV(DPPIV)andactivatesJNKandp38MAPkinases.AEBSFisab-secretaseinhibitorthathasbeenshowntoinhibitbetaamyloidpeptideproductionandenhanceAPP(amyloidprecursorprotein)secretioninseveralcelllinesatmillimolarconcentrations.
AdditionalInformation
| Synonyms | Pefabloc |
|---|---|
| Product# | A-1018 |
| CAS# | 30827-99-7 |
| ChemicalName | 4-(2-Aminoethyl)-bezenesulfonylfluoride.HCl |
| Formula | C8H10FNO2S.HCl |
| MW | 239.5 |
| Appearance | Off-WhiteSolid |
| Purity | 98% |
| Solubility | DMSO,Methanol:Clearpurplesolutionat10mg/ml. |
| MeltingPoint | 182-184°C |
| StorageTemp | -20°C |
| Use | AEBSFisabroadspectrum,watersoluble,irreversibleserineproteaseinhibitor |
| MDLNumber | MFCD00132962 |
|---|---|
| ChemACX | X1086833-8 |
| InChI | InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H |
| SMILES | c1cc(ccc1CCN)S(=O)(=O)F.Cl |
