Theperoxisomeproliferator-activatedreceptor(PPAR)-αactivator,5,8,11,14-eicosatetraynoicacid(ETYA),isanarachidonicacidanalog.Itisreportedtoinhibitup-regulationofpro-inflammatorygenes.Amongtheinflammatorychemokineselaborated,glialcell-derivedCCL2/MCP-1iscrucial,itpromotesthemigrationandrecruitmentofinflammatorycells,itisprimarilyresponsIBLefortheinitiationandprogressionofinflammatoryresponsesinneurodegenerativediseaseandalsoassociatedwithavarietyofdisease,includingatherosclerosis.
ETYAhasananti-inflammatorymechanism,byincreasingHuR-mediated-MKP-1mRNAstABIlitythatleadstothespecificsuppressionofCCL2/MCP-1duringinflammatoryprocesses.StudieshaveshownthatETYAincreasesMKP-1expressionthroughHuRatthepost-transcriptionallevelinareceptor-independentmanner. TherebyprovidingevidencethatETYAisapotentialtherapeuticmodulatorofinflammation.ETYA"sinfluenceon suppressingCCL2/MCP-1expressionisanemergingtherapeuticstrategyforthetreatmentofneurodegenerativediseasessuchas Alzheimer"sdisease,multiplesclerosis,andbrainischemia.
Arecentresearchregardingupperaerodigestivecancer(anaggressivemalignancy)hasrevealedthatPPARγpathwayswouldbeanoveltherapyforthiscancer.ETYAisaPPARγactivatorandresultsfromthisstudyhaveshownthatitdownregulatescellproliferationandhasantineoplasticfeatures.
AdditionalInformation
| Synonyms | Eicosatetraynoicacid;5,8,11,14-Eicosatetraynoicacid |
|---|---|
| Product# | E-2000 |
| CAS# | 1191-85-1 |
| ChemicalName | Octadehydroarachidonicacid,Eicosatetraynoicacid |
| Formula | C20H24O2 |
| MW | 296.5 |
| Appearance | OffWhitetoWhiteSolid |
| Purity | ≥98% |
| Solubility | Solubleinethanol,methanol,orDMSO. |
| StorageTemp | +4°C |
