AG Scientific/Alamethicin/5 mg/A-1286-5 mg
商品编号：
A-1286-5mg
品牌：
agscientific
市场价：
¥3263.80
美元价：
2447.85
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
Antibiotic U-22324
SKU
A-1286
CAS #
27061-78-5
Chemical Name
(4S)-4-[[2-[[2-[[(2S)-2-[[(2S)-1-[2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-1-(2-acetamido-2-methylpropanoyl)pyrrolidine-2-carbonyl]amino]-2-methylpropanoyl]amino]propanoyl]amino]-2-methylpropanoyl]amino]propanoyl]amino]-5-
Chemical Formula
C92H150N22O25
Molecular Weight
1964.4 Da
Appearance
Off-white to beige powder
Purity
>99% by TLC
Solubility
DMSO: 10 mg/mL clear solution; CH3OH: 10 mg/mL clear solution
Melting Point
268-271°C
Preparation
Store Solutions at -20°C for up to 2 months.
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Alamethicin is an antibiotic that functions as a monovalent cation ionophore. It has been used to develop methods for the routine assessment of potential new drug candidates to elicit their pharmacokinetic drug interactions. Alamethicin forms voltage-dependent ion channels in the lipid bilayer, and this channel-forming activity has been exploited as a tool for introducing hydrophilic small molecules into mitochondria without disrupting the integrity of the membrane.
Merck Index
N/A
MDL NUMBER
MFCD00151517
CHEMACX
X1009632-9
INCHI
InChI=1S/C92H150N22O25/c1-47(2)43-58(72(127)108-92(24,25)84(139)113-41-29-33-59(113)73(128)103-65(48(3)4)75(130)111-90(20,21)82(137)112-89(18,19)80(135)102-56(37-40-64(120)121)70(125)101-55(35-38-61(93)117)69(124)98-54(46-115)44-53-31-27-26-28-32-53)99-63(119)45-95-77(132)85(10,11)110-76(131)66(49(5)6)104-81(136)88(16,17)107-71(126)57(36-39-62(94)118)100-67(122)50(7)96-78(133)86(12,13)106-68(123)51(8)97-79(134)87(14,15)109-74(129)60-34-30-42-114(60)83(138)91(22,23)105-52(9)116/h26-28,31-32,47-51,54-60,65-66,115H,29-30,33-46H2,1-25H3,(H2,93,117)(H2,94,118)(H,95,132)(H,96,133)(H,97,134)(H,98,124)(H,99,119)(H,100,122)(H,101,125)(H,102,135)(H,103,128)(H,104,136)(H,105,116)(H,106,123)(H,107,126)(H,108,127)(H,109,129)(H,110,131)(H,111,130)(H,112,137)(H,120,121)/t50-,51-,54+,55-,56-,57-,58-,59-,60-,65-,66-/m0/s1
SMILES
C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C)(C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc2ccccc2)CO)NC(=O)C(C
Peptide sequence
AC-AIB-PRO-AIB-ALA-AIB-ALA-GLN-AIB-VAL-AIB-GLY-LEU-AIB-PRO-VAL-AIB-AIB-GLU-GLN-PHENYLALANINOL
RTECS
Not Applicable
UN #"S
UN 3288
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
WARNING: TOXIC! Use only in area provided with appropriate exhaust ventilation. Keep away from heat andsource of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
msds 1
A-1286, Alamethicin, SDS, diamond format.pdf
Certificate of Analysis 1
A-1286, J1079A.pdf
Certificate of Analysis 2
A-1286, J1079.pdf
Certificate of Analysis 3
A-1286, H1379.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
