AG Scientific/Trichostatin A/1 mg/T-1052-1 mg
商品编号：
T-1052-1mg
品牌：
agscientific
市场价：
¥2134.80
美元价：
1601.10
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
TSA; TSN
SKU
T-1052
CAS #
58880-19-6
Chemical Name
N/A
Chemical Formula
C17H22N2O3
Molecular Weight
302.4 Da
Appearance
Beige powder
Purity
≥98%
Solubility
May be dissolved in DMSO (15 mg/mL); or Ethanol (3 mg/mL).
Melting Point
150-151°C
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Inflammatory diseases
USE
Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of histone deacetylases (HDAC). In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression and displayed immunosuppressive activity in a mouse model. Induces increased acetylation of GATA4, a cardiac-specific transcription factor and increases cardiac muscle cell differentiation. In normal fibroblasts, induced Friend cell differentiation and inhibited the G1 and G2 phases of the cell cycle. TSA is a useful tool for induction of hyperacetylation of cellular histones and for further elucidation of their role in gene expression.
Merck Index
N/A
RTECS
MI5215000
Handling
Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaustventilation.
Citations
DEVELOPMENT/PLASTICITY/REPAIR:Epigenetic Enhancement of BDNF Signaling Rescues Synaptic Plasticity in AgingYan Zeng, Miao Tan, Jun Kohyama, Marissa Sneddon, Joseph B. Watson, Yi E. Sun, and Cui-Wei XieJ. Neurosci., Dec 2011; 31: 17800 - 17810.
Citations_Hyperlink
http://www.jneurosci.org/cgi/reprint/31/49/17800
Certificate of Analysis 1
T-1052, J1211.pdf
Certificate of Analysis 2
T-1052, J1134.pdf
Certificate of Analysis 3
T-1052, G1001.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
