AG Scientific/Lactacystin/200 ug/L-1147-200 ug
商品编号：
L-1147-200ug
品牌：
agscientific
市场价：
¥2980.00
美元价：
2235.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
N-Acetyl-S-{[(2R,3S,4R)-3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinyl]carbonyl}-L-cysteine
SKU
L-1147
CAS #
133343-34-7
Chemical Name
(2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid
Chemical Formula
C15H24N2O7S
Molecular Weight
376.4 Da
Appearance
Lyophilized or white crystalline solid
Purity
≥98%
Solubility
Soluble in DMSO, water or ethanol
Melting Point
236 – 238°C
Preparation
N/A
Storage Temp
-20°C, desiccated, store up to 1 month.
THERAPEUTIC AREA
Not Applicable
USE
Lactacystin is a potent and selective irreversible proteasome inhibitor and cathepsin A inhibitor. Lactacystin is a microbial metabolite isolated from Streptomyces first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins. Thus, the effects of this substance are pleiotropic and depend substantially on the expression pattern of signaling proteins within the treated cell. It is shown to inhibit cell proliferation and to induce neurite outgrowth in murine neuroblastoma cell lines such as Neuro 2a.
Merck Index
N/A
RTECS
N/A
Handling
Keep container tightly closed in a dry and well-ventilated place. Provide appropriate exhaust ventilation at places where dust is formed.
Citations
MYELOID NEOPLASIA:Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2AArelis Salas, Suriyan Ponnusamy, Can E. Senkal, Marisa Meyers-Needham, Shanmugam Panneer Selvam, Sahar A. Saddoughi, Elif Apohan, R. David Sentelle, Charles Smith, Christopher R. Gault, Lina M. Obeid, Hesham M. El-Shewy, Joshua Oaks, Ramasamy Santhanam, Guido Marcucci, Yusuf Baran, Sandeep Mahajan, Daniel Fernandes, Robert Stuart, Danilo Perrotti, and Besim OgretmenBlood, Jun 2011; 117: 5941 - 5952.
Citations_Hyperlink
http://bloodjournal.hematologylibrary.org/cgi/reprint/117/22/5941
msds 1
L-1147, Lactacystin, SDS, diamond format.pdf
Certificate of Analysis 1
L-1147, J1275.pdf
Certificate of Analysis 2
L-1147, J1025A.pdf
Certificate of Analysis 3
L-1147, J1025.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
