AG-Scientific/依托泊苷/500毫克/E-2004-500毫克
商品编号：
E-2004-500mg
品牌：
agscientific
市场价：
¥5099.80
美元价：
3059.88
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
VePesid; Toposar; Lastet; Zuyeyidal; Etoposidum; Etoposido; Eposin
SKU
E-2004
CAS #
33419-42-0
Chemical Name
(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Chemical Formula
C29H32O13
Molecular Weight
588.6 Da
Appearance
White solid
Purity
≥98%
Solubility
Soluble in DMSO (25 mg/mL)
Melting Point
236-251 °C
Preparation
N/A
Storage Temp
Desiccated at -20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Etoposide (VP-16) is a Topo II (topoisomerase II) inhibitor that is widely used as an apoptosis inducer. Etoposide exhibits antineoplastic and anti-mitotic properties, as well as, inhibits DNA synthesis and induces double-strand and single-strand DNA breaks. Etoposide is cell-cycle dependent and cell-cycle specific to late S and G2 phases, activates p53, resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells. Etoposide (VP-16) is an inhibitor of NCoA-3.
MDL NUMBER
MFCD00869325
CHEMACX
X1004425-4
INCHI
InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
SMILES
C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@@H]3c4cc5c(cc4[C@H]([C@@H]6[C@@H]3COC6=O)c7cc(c(c(c7)OC)O)OC)OCO5)O)O
Peptide sequence
Not Applicable
RTECS
KC0190000
UN #"S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
Certificate of Analysis 1
E-2004, J1005C.pdf
Certificate of Analysis 2
E-2004, J1005B.pdf
Certificate of Analysis 3
E-2004, J1005A.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
