AG Scientific/Streptozotocin/5 gm/S-2044-5 gm
商品编号：
S-2044-5gm
品牌：
agscientific
市场价：
¥10568.00
美元价：
6340.80
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
Streptozocin; STZ; Zanosar
SKU
S-2044
CAS #
18883-66-4
Chemical Name
1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
Chemical Formula
C8H15N3O7
Molecular Weight
265.2 Da
Appearance
Pale yellow powder
Purity
≥97%
Solubility
Soluble in water, ethanol or DMSO at 50 mg/mL.
Melting Point
121 °C
Preparation
N/A
Storage Temp
-20°C, Warning: Harmful!
THERAPEUTIC AREA
Endocrinological Disorders
USE
Streptozotocin (STZ) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals . STZ is a potent alkylating agent known to directly methylate DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. This antibiotic was found to be mutagenic in bacterial assays and eukaryotic cells. STZ is also carcinogenic; a single administration induces tumors in rat kidney, liver, and pancreas. Several lines of evidence indicate that free radicals are involved in the production of DNA and chromosome damage by this compound.
Merck Index
Merck Index: 13.8912
MDL NUMBER
MFCD00006607
CHEMACX
X1005022-7
INCHI
InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
SMILES
CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O
Peptide sequence
Not Applicable
RTECS
LZ5775000
UN #"S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed
Certificate of Analysis 1
S-2044, H1006D.pdf
Certificate of Analysis 2
S-2044, H1006C.pdf
Certificate of Analysis 3
S-2044, H1006B.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
