AEBSF hydrochloride; AEBSF; Pefabloc; Pefabloc SC; 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

A-1018

30827-99-7

4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride

C₈H₁₁ClFNO₂S

239.69 Da

White to off-white powder

≥97% (HPLC)

Clear colorless solution in H2O 50mg/ml

182-184 °C

N/A

-20°C, desiccated

Not Available

The benzenesulfonyl fluoride derivative AEBSF is more stable in physiological medium than PMSF, is commercially available, and is widely used as a broad-spectrum serine protease inhibitor. AEBSF inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. AEBSF also inhibits activation of TGFβ, DPP IV and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines. AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins (SREBP). By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

N/A

MFCD00132962

X1086833-8

186136

WRDABNWSWOHGMS-UHFFFAOYSA-N

C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl

UN 3261

II

Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.

A-1018, AEBSF HCL, SDS, diamond format.pdf

A-1018, J1257B.pdf

A-1018, J1257A.pdf

A-1018, J1257.pdf