Tunicamycinisanantibiotic isolatedfrom StreptomycesIysosuperficus usefulinglycoproteinresearch.Thiscompoundisnotedtobeactive invitro againstgram-positivebacteria,fungi,yeasts,andviruses.ItisaninhibitorofN-linkedglycosylationandtheformationofN-glycosidicprotein-carbohydratelinkages. Duringproteinglycosylation,tunicamycinisnotedtoinhibitthetransferofsaccharidemoietiestodolicholduringdolichol-linkedglycoproteinsynthesis.Dose-dependentinhibitionofDNAsynthesismayberelatedtothealterationofglycoproteins,whichtherebyaffectsthetransportofthymidineintocells.Additionally,tunicamycinhasbeenreportedtopreventcellcycleprogressioninprimaryculturesofratglialcells,aswellasinhibitlipid-mediatedproteinglycosylationinchickormousefibroblastsinadose-dependentmanner.
AdditionalInformation
| Product# | T-1016 |
|---|---|
| CAS# | 11089-65-9 |
| Formula | C39H64N4O16 |
| MW | 840.0 |
| Appearance | Off-whitePowder |
| Purity | >99% |
| Solubility | DMSO(10mg/ml)orEtOH |
| MeltingPoint | 258-260‚°C |
| StorageTemp | -20°C,Warning!Toxic.MaybeCarcinogenic.Weargloves/maskwhenhandlingproduct.Avoidcontactbyallmeansofexposure. |
| MerckIndex | 13.6888.2001 |
|---|
