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AG Scientific/Oligomycin A, Streptomyces diastatochromogenes/O-1063/5 mg
OligomycinAisacomponentoftheoligomycincomplex(O-1060).ItisaninhibitorofATPsynthase.Inoxidativephosphorylationresearch,itisusedtopreventstate3(phosphorylating)respiration. OligomycinAinhibits ATPsynthasebyblockingitsprotonchannel(Fosubunit),whichisnecessaryfor oxidativephosphorylation of ADP to ATP (energyproduction).TheinhibitionofATPsynthesisbyoligomycinAwillsignificantlyreduceelectronflowthroughthe electrontransportchainhowever,electronflowisnotstoppedcompletelyduetoaprocessknownasprotonleakormitochondrialcoupling.Thisprocessoccursduetothe facilitateddiffusion ofprotonsintothe mitochondrialmatrix throughan uncouplingprotein suchas Thermogenin,or UCP1.
OligomycinAstimulateslysosomeacidificationduetoshuntingofmembranepotential.Inducesapoptosisinavarietyofcelltypes.OligomycinAalsoinducesautophagyintheIPLB-LdFBinsectcellline.
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AdditionalInformation
| Product# | O-1063 |
|---|---|
| CAS# | 579-13-5 |
| ChemicalName | (1R,2"R,4E,5"S,6S,6"S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-ETHYL-7,11,14,15-TETRAHYDROXY-6"-((R)-2-HYDROXYPROPYL)-5",6,8,10,12,14,16,28,29-NONAMETHYL-3",4",5",6"-TETRAHYDRO-2,26-DIOXASPIRO[BICYCLO[23.3.1]NONACOSA[4,18,20]TRIENE-27,2"- |
| Formula | C45H74O11 |
| MW | 791.07 |
| Appearance | WhitetoLightBrownSolid |
| Purity | 95% |
| Solubility | SolubleinDMSO |
| MeltingPoint | 140-141°C |
| BoilingPoint | 886.3±65.0°Cat760mmHg |
| StorageTemp | +4°C |
| TherapeuticArea | InfectiousDiseases |
| Use | AmitochondrialATPaseinhibitoruseasantibiotics,antifungalactivities. |
| MerckIndex | 13.6902.2001 |
|---|---|
| MDLNumber | MFCD00065705 |
| ChemACX | X1094055-9 |
| InChI | InChI=1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31-,32-,33-,34-,35-,36-,38+,40+,41+,42-,44+,45-/m1/s1 |
| SMILES | CC[C@H]1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C |
