Cycloheximideisanantibioticactiveagainstmanyyeastsandfungi.Inhibitsproteinsynthesisineukaryotes(butnotinprokaryotes)byinterferingwiththetranslocationstep.Itinhibitschaininitiationaswellaschainelongationbyactingonthe60Ssubunitoftheeukaryoteribosome,interactingdirectlywithenzymetranslocase.Cycloheximideisusedasaninhibitortostudycell-freeproteinbiosynthesisineukaryotesandalsousedtoblockribosome-dependentinvivopolypeptidesynthesis.Itinducesapoptosisinavarietyofcells,butcanalsodelayorinhibitapoptosisbyotheragents.
Cycloheximide’s longstandingapplicationasageneselectionantibiotic hasapowerfulnewroleinGenomeeditingutilizingtheCRISPR/Cas9system. ACandidaalbicansCRISPRsystempermitsgeneticengineeringofessentialgenesandgenefamilies.
Cycloheximideisinstock.Callforbulkquotations,typicalleadforsuBDivision,packingandshippinglargerquantitiesis7-14days.
Researchsizeorder100mg250mgleadisshorter.
InternationalShippingofthismaterialcanbesubjecttoanadditionalhazardousshippingfee.
AdditionalInformation
| Synonyms | Actidione,NaramycinA,NSC-185,U-4527 |
|---|---|
| Product# | C-1189 |
| CAS# | 66-81-9 |
| ChemicalName | 4-[(2R)-2-[(1S,3S,5S)-3,5-DIMETHYL-2-OXOCYCLOHEXYL]-2-HYDROXYETHYL]PIPERIDINE-2,6-DIONE |
| Formula | C15H23NO4 |
| MW | 281.3 |
| Appearance | WhiteSolid |
| Purity | 95% |
| Solubility | SolubleinChloroform,EthanolandMethanol. |
| BoilingPoint | 491.8±10.0°Cat760mmHg |
| Preparation | Storesolutionsat-20°C |
| StorageTemp | +4°C |
| TherapeuticArea | InfectiousDiseases |
| Use | Cycloheximideisahighlyeffectiveantibioticwithactivityagainstmold,yeast,andphytopathogenicfungi,withloweractivityagainstbacteria |
| MDLNumber | MFCD00082346 |
|---|---|
| ChemACX | X1006248-5 |
| InChI | InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 |
| SMILES | C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C |
