AG Scientific/Siomycin A/S-2771/0.5 mg
商品编号：
S-2771-0.5mg
品牌：
agscientific
市场价：
¥6927.80
美元价：
4156.68
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
*PleaseinquiretheavailABIlityforthisproduct.Siomycinisamacrocyclicantibioticwithpotentandselectiveantibacterialactivitydiscoveredin1969.Siomycinisapotentinhibitoroftheoncogenictranscriptionfactor,FoxM1.ThereducedtranscriptionactivityisreflectedinthedownregulationofproteinandmRNAlevelsofFoxM1andeffectsondownstreamgenes,Cdc25B,survivinandCENPB.Invitro,siomycininhibitsFoxM1-inducedcellgrowthonsoftagarandselectivelykillstransformedbutnotnormalcells.
AdditionalInformation
| Synonyms | Mutabilycin,Sporangiomycin,6741-21,Mutabillicin |
|---|---|
| Product# | S-2771 |
| CAS# | 12656-09-6 |
| Formula | C71H81N19O18S5 |
| MW | 1648.9 |
| Appearance | Whitesolid |
| Purity | >95%byHPLC |
| Solubility | DMSOandDMF,partiallysolubleinmethanolandethanolwhilepoorlysolubleinwater |
| StorageTemp | -20°C |
| TherapeuticArea | InfectiousDiseases |
| Use | Siomycinisamacrocyclicantibioticwithpotentandselectiveantibacterialactivity |
| MDLNumber | MFCD01750111 |
|---|---|
| InChI | InChI=1S/C71H81N19O18S5/c1-14-37-64-83-44(22-109-64)61(103)89-52(70(13,107)34(12)93)67-85-43(23-112-67)59(101)88-48-33(11)108-68(106)40-19-36(31(9)91)35-15-16-38(50(94)49(35)79-40)78-46(25(2)3)62(104)77-29(7)56(98)74-27(5)55(97)75-30(8)57(99)90-71(69-86-45(24-113-69)60(102)87-47(32(10)92)63(105)81-37)18-17-39(80-51(71)41-20-111-66(48)82-41)65-84-42(21-110-65)58(100)76-28(6)54(96)73-26(4)53(72)95/h14-16,19-21,23-25,30-34,38,44,46-48,50-52,78,91-94,107H,4-7,17-18,22H2,1-3,8-13H3,(H2,72,95)(H,73,96)(H,74,98)(H,75,97)(H,76,100)(H,77,104)(H,81,105)(H,87,102)(H,88,101)(H,89,103)(H,90,99)/b37-14-/t30-,31-,32+,33+,34+,38+,44+,46-,47-,48-,50-,51+,52+,70+,71+/m0/s1 |
| SMILES | C/C=C1/C2=N[C@H](CS2)C(=O)N[C@H](c3nc(cs3)C(=O)N[C@@H]4c5nc(cs5)[C@@H]6[C@](CCC(=N6)c7nc(cs7)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)(c8nc(cs8)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)[C@@H](NC(=O)C(=C)NC(=O)C(=C)NC(=O)[C@@H](N[C@@H]9C=Cc1c(cc(nc1[C@H]9O)C(=O)O[C@@H]4C)[C@H](C)O)C(C)C)C)[C@@](C)([C@@H](C)O)O |
