4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
agscientific(优势品牌)
主营:嘌呤霉素,G-418,酶抑制剂,基因选择,抗生素和蛋白质纯化试剂
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > Stimulus > AG Scientific/DTE (1,4-Dithioerythritol)/1 g/D-2589-1 g
商品详细AG Scientific/DTE (1,4-Dithioerythritol)/1 g/D-2589-1 g
AG Scientific/DTE (1,4-Dithioerythritol)/1 g/D-2589-1 g
AG Scientific/DTE (1,4-Dithioerythritol)/1 g/D-2589-1 g
商品编号: D-2589-1g
品牌: agscientific
市场价: ¥815.80
美元价: 611.85
产地: 美国(厂家直采)
公司:
产品分类: 刺激/抑制试剂
公司分类: Stimulus
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Cat#:ACC-116
AlternativeNameInositol1,4,5-trisphosphatereceptortype2,IP3R2,InsP3R2,IP3receptorisoform2
  • LyophilizedPowder
  • AntigenIncl.
  • Type:Polyclonal
    Host:Rabbit
    Reactivity:r
    Mayalsoworkin:h*,m*
      • Peptide(C)RLGFLGSNTPHENH,correspondingtoaminoacidresidues2683-2696ofratIP3R2(Accession P29995). Intracellular,C-terminus.
        Anti-IP3 Receptor-2 (ITPR2) Antibody
    Accession(Uniprot)NumberP29995
    GeneID81678
    PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.
    HomologyMouse,human-13/14aminoacidresiduesidentical.
    RRIDAB_2340910.
    PurityAffinitypurifiedonimmobilizedantigen.
    FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN3.
    IsotypeRabbitIgG.
    StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.
    Reconstitution25µl,50µlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.
    Antibodyconcentrationafterreconstitution0.8mg/ml.
    StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).
    NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.
    Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).
    Negativecontrolantigenstorageafterreconstitution-20°C.
    PreadsorptionControl1µgpeptideper1µgantibody.
    StandardqualitycontrolofeachlotWesternblotanalysis.
    Applications:if,ih,wb
    Mayalsoworkin:ic*,ifc*,ip*
      • Anti-IP3 Receptor-2 (ITPR2) Antibody
        Westernblotanalysisofratbrainmembrane(lanes1and3)andratbasophilicleukemia(RBL)celllinelysate(lanes2and4):
        1,2. Anti-IP3 Receptor-2 (ITPR2) Antibody(#ACC-116),(1:200).
        3,4.Anti-IP3 Receptor-2(ITPR2)Antibody,preincubatedwiththenegativecontrolantigen.
      • Anti-IP3 Receptor-2 (ITPR2) Antibody
        ExpressionofIP3R2inratspinalcord
        ImmunohistochemicalstainingofIP3R2inratspinalcordsectionsusing Anti-IP3 Receptor-2(ITPR2)Antibody(#ACC-116). A.IP3R2immunoreactivity(red)appearsinneuronalsoma(horizontalarrows)andprocesses(verticalarrows).B.NuclearstainingusingDAPIasthecounterstain(blue).C.MergedimageofAandB.
    References
    • 1.Furuichi,T.etal.(1989)Nature342,32.
    • 2.Berridge,M.J.etal.(2003)Nat.Rev.Mol.CellBiol.4,517.
    • 3.Furuichi,T.etal.(1994)Curr.Opin.Neurobiol.4,294.
    • 4.Varnai,P.etal.(2005)Proc.Natl.Acad.Sci.U.S.A.102,7859.
    • 5.Fujino,I.etal.(1995)CellTissueRes.280,201.
    • 6.Yaroslavskiy,B.B.etal.(2007)J.CellSci.120,2884.
      • Inositol1,4,5-trisphosphatereceptors(IP3R)areintracellularCa2+ releasechannelslocatedontheendoplasmicreticulum(ER)andmediateCa2+ mobilizationfromtheERtothecytoplasminresponsetothebindingofthesecondmessenger,inositol1,4,5-trisphosphate(IP3)1.IP3-inducedCa2+ releaseistriggeredbyvariousexternalstimuli,andmostnon-excitablecellsusethismechanismastheprimaryCa2+ signalingpathway.IP3Rsarethereforethoughttohaveimportantphysiologicalrolesinvariouscelltypesandtissues2.

        ThreesubtypesofIP3Rs,derivedfromthreedistinctgenes,havebeenidentifiedinmammals3.AllthreereceptorshavesixtransmembranedomainsandaporeregionbetweenTM5andTM6.TheN-terminusaswellastheC-terminusarecytoplasmic.EachIP3RconsistsofanN-terminalligandbindingdomain(LBD)andaC-terminaldomainwhichislinkedbyalongregulatorydomain.TheC-terminusisconstitutivelyactive,suggestingthattheregulatorydomainisrequiredtomaintainthesuppressionofchannelactivity4

        Type2IP3R(IP3R2)isexpressedinvarioustissuesandcelllines.IP3R2mRNAislocalizedintheintralobularductcellsofthesuBMAndibulargland,theurinarytubulecellsofthekidney,theepithelialcellsofepididymalductsandthefolliculargranulosacellsoftheovary5.IP3R2isactiveduringosteoclastdifferentiation,anditsabsencecausesapartialdefectinosteoclasticdifferentiation.

    Applicationkey:

    CBE-Cell-basedELISA,FC-Flowcytometry,ICC-Immunocytochemistry,IE-IndirectELISA,IFC-Indirectflowcytometry,
    IF-Immunofluorescence,IHC-Immunohistochemistry,IP-Immunoprecipitation,LCI-Livecellimaging,N-Neutralization,WB-Westernblot

    Speciesreactivitykey:

    H-Human,M-Mouse,R-Rat
    receivea25µlfreetrialsample!
    Lastupdate:10/11/2019

    Anti-IP3Receptor-2(ITPR2)Antibody(#ACC-116)isahighlyspecificantibodydirectedagainstanepitopeoftheratprotein.Theantibody canbeusedinwesternblotandimmunohistochemistryapplications.IthasbeendesignedtorecognizeIP3R2fromrat,mouseandhumansamples.

    Forresearchpurposesonly,notforhumanuse
    品牌介绍
    AG Scientific, Inc.成立于1997年,专注于创新生化制剂以及用于诊断测试开发的定制原材料,以推进临床前研究药物开发。产品涉及抗生素,生物洗涤剂,缓冲液,诊断,酶,医疗设备试剂,蛋白酶K,还原剂,RNase A等。