AG Scientific/Aphidicolin/5 mg/355.69
商品编号：
355.69
品牌：
agscientific
市场价：
¥0.00
美元价：
0.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
More Information
Alternate Name/Synonyms
APC; ICI 69653; NSC 234714
SKU
A-1026
CAS #
38966-21-1
Chemical Name
(1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
Chemical Formula
C20H34O4
Molecular Weight
338.5 Da
Appearance
White Powder
Purity
>99% (TLC)
Solubility
Methanol: Clear colorless solution at 10 mg/ml
Melting Point
230°C
Preparation
N/A
Storage Temp
+4°C
THERAPEUTIC AREA
Not Available
USE
For research use only. Not intended for diagnostic or therapeutic use. Aphidicolin is a tetracyclic diterpene with antibiotic, antiviral and antimitotic properties by blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.
Merck Index
Merck Index: 13.734.2001
MDL NUMBER
MFCD00083214
CHEMACX
X1001937-7
INCHI
InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
SMILES
C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
Peptide sequence
Not Applicable
RTECS
PB9185000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Warning.Toxic. Potential Carcinogenic. Do not use this compound if you are not fully trained or are unaware of the hazards involved. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Avoid contact with skin, eyes or clothing. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
Citations
CELL BIOLOGY:Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesionAndrea L. Lafont, Jianhua Song, and Susannah RankinPNAS, Nov 2010; 107: 20364 - 20369.
Citations_Hyperlink
http://www.pnas.org/cgi/reprint/107/47/20364
Certificate of Analysis 1
A-1026, J1034E.pdf
Certificate of Analysis 2
A-1026, J1034D.pdf
Certificate of Analysis 3
A-1026, J1034C.pdf
品牌介绍
AG Scientific, Inc.成立于1997年，专注于创新生化制剂以及用于诊断测试开发的定制原材料，以推进临床前研究药物开发。产品涉及抗生素，生物洗涤剂，缓冲液，诊断，酶，医疗设备试剂，蛋白酶K，还原剂，RNase A等。
